Lymphoma is a type of cancer that impacts the body’s lymphatic system. It originates from a type of white blood cells called Lymphocytes which are part of the lymphatic system. Many subtypes of lymphoma are known. The 2 main categories are the non-hodgkin lymphoma (NHL) which makes up to 90% of lymphoma occurrence, and Hodgkin Lymphoma. Lymphomas, leukemias, and myelomas are part of the broader group of tumors of hematopoietic and lymphoid tissues.
Patients with lymphoma often notice a swelling of their lymph nodes that are caused by the formation of painless lumps or tumors. Clusters of lymph nodes are located in the neck, armpits and groins. Lymphoma patients might have growth in these regions. Risk factors for Hodgkin Lymphoma include Epstein-Barr virus and genetic occurrence in family. Risk factors for the most common type of Non-Hodgkin Lymphoma include autoimmune disease, HIV/AIDS, and infection with human T-lymphotropic virus.
Disclaimer: The information presented in this website is only for education purposes. This information does not substitute nor replace medical advice.
Hodgkin’s Lymphoma (10% of cases)
Patients with Hodgkin Lymphoma often have large abnormal cells called Reed-Sternberg cells in their lymph nodes. This disease has a high percentage of treatment success. Hodgkin lymphoma is most prevalent in people between 15 and 40 years of age and people aged 55 years and above.
Non-Hodgkin’s Lymphoma
- Aggressive (high grade) Non-Hodgkin’s Lymphoma grow and spread rapidly and cause severe symptoms. If left untreated, this lymphoma can be fatal within a few months time
- Slow-growing (low grade) Non-Hodgkin’s Lymphoma grow and spread slowly and cause few symptoms. This type of lymphoma is harder to treat and carries a high chance or relapse
Treatments of lymphoma may include chemotherapy, radiation therapy and proton therapy. In some Non-Hodgkin Lymphoma, an increased amount of protein produced by lymphoma cells cause the blood to thicken that plasmapheresis might be needed to remove the protein.
Based on the types of Lymphocytes from which Lymphoma originates, lymphomas can also be classifed as B cell or T cell Lymphoma. B-cell Lymphomas are much more common than T-cell Lymphomas.
Signs & Symptoms of Lymphoma
When someone has non-specific symptoms, lymphoma may still be present. If symptoms are persistent, a medical evaluation to determine the cause needs to be undertaken:
1. Lymphadenopathy (swelling of lymph nodes)
This is the primary presentation of lymphoma. Generally, the patient doesn’t feel any pain.
2. B Symptoms (systemic symptoms)
These symptoms can be associated with both Hodgkin and non-Hodgkin Lymphoma. They consist of fever, night sweats and weight loss.
3. Other Symptoms
Anemia, bleeding, increased susceptibility to infections, loss of appetite/anorexia and fatigue
Diagnosis of Lymphoma
Lymph-node biopsy is the main method to diagnose lymphoma, meaning a partial or total excision of lymph nodes being examined under the microscope. This examination may reveal histophathological features that indicate the presence of lymphoma. Some other tests that might be carried out to identify types of lymphoma include Immunophenotyping, Flow Cytometry and Fluorescence in situ hybridization testing.
After a diagnosis and before treatment, cancer is differentiated by stages. The staging process determines whether the cancer has spread, and if so, whether locally or to a different site. The Ann Arbor staging system is routinely used to stage both Hodgkin and Non-Hodgkin Lymphoma.
Stage 1: Localized disease contained within a lymph node group
Stage 2: Presence of lymphoma in 2 or more lymph node groups
Stage 3: Spread of the lymphoma to lymph node groups on both sides of the diagram
Research of TXL on Lymphoma
In 2005, the research team of Andy Sun from National Taiwan University conducted a research to investigate apoptosis (programmed cell death) effect of TXL (THL in Taiwanese pronounciation) towards various cancer cells, including lymphoma cell lines. The research was published in the Journal of Alternative & Complementary Medicine.
Objective: Tien-Hsien liquid (THL) is a commercially available Chinese herbal mixture that has been used as an anti-cancer dietary supplement for more than 10 years. We recently showed that TXL has strong immunomodulatory effects on peripheral blood mononuclear cells (PBMC) and T cells. To investigate the anti-tumor activity of TXL further, we sought to test whether TXL could induce apoptosis in various human cancer cell lines based on the fact that TXL contains several components with tumor killing functions.
Results: TXL could induce apoptosis in all human cancer cell lines tested but not in normal human cells. TXL treatment of H1299 cancer cells resulted in activation of caspase-8, -9, and -3 and the inhibitors of these caspases could partially block THL-induced apoptosis.
Conclusions: TXL has been used by numerous patients with cancer for many years with no known adverse effect. Our present study showing that TXL had a broad-range tumor killing function has provided a molecular basis underlying TXL therapeutic activity. Furthermore, because TXL had apoptotic effects only on cancer cells but not on normal cells, this selectivity suggests that TXL could be a potential cancer therapeutic agent.
U937 refers to the human hystiocytic lymphoma cell line.
Table 1a: Cells were treated with 1% (v/v) THL and subjected to TUNEL staining
Table 1b: +++ means more than 80% of cells were TUNEL positive (undergoing apoptosis/programmed cell death)
++ means 40%-80% of cells were TUNEL positive
+ means about 10% of cells were TUNEL positive
– means less than 0.1% of cells were TUNEL positive
Table 1 shows that by method of TUNEL assays, the research demonstrates that TXL has apoptosis-inducing effects on a broad spectrum of human cancer cell lines including lymphoma cell lines, but TXL does not harm the normal HUVEC and PBMC cells.
This means that TXL selectively induces apoptosis (programmed cell death) only on human cancer cell lines, without harming normal cells.
TXL Supports Lymphoma Treatment in Singapore
TXL Phytoceutical has been used in international market since 1991. After 30 years of experience in supporting cancer patients, today the Research of TXL towards cancer has produced 26 international published peer-reviewed research articles, including 2 clinical researches, one for Breast Cancer in Taiwan National Hospital, and the other one for Nasopharyngeal Cancer in Dharmais Hospital Jakarta Indonesia.
TXL is also recognized in the Drug Dictionary of National Cancer Institute with code name THL-P.
There are 4 main therapeutic functions of TXL verified by its 26 researches:
1. Increase in Quality of Life
Research shows that TXL helps to improve the Quality of Life in cancer patients. Patients who consume TXL experience better physical and cognitive functions, with less fatigue.
2. Immunomodulating Effect
Immunomodulating means the ability to stimulate or regulate immune system which may help the body fight cancer, infection, or other diseases. TXL helps to stimulate Lymphocytes (by elevating CD3, CD4/CD8 and CD19), which are a crucial part of the immune system responsible to fight cancer cells, viruses and bacteria. The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a central focus for engaging the immune system in the fight against cancer. Basic science discoveries elucidating the molecular and cellular biology of the T cell have led to new strategies in this fight, including checkpoint blockade and adoptive cellular therapy.
Aside from T Lymphocytes, other classes of Lymphocytes include Natural Killer Cells, T Helper Cells, and B Cells.
3. Induce Apoptosis
4. Inhibition of Metastasis & Angiogenesis
Metastasis means the migration or invasion of cancer cells from its’ primary location to another organ. This spreading of cancer is the main cause of death of patients with malignancy. Metastasis of cancer cells involves multiple processes and various cytophysiological changes.
Angiogenesis, the process of new blood vessel formation, plays a crucial role in the growth and metastasis of tumors. Tumor growth and progression require angio-genesis because in its absence tumor growth is restricted to a few millimeters in diameter due to the physical constraint set by simple diffusion of nutrients and oxygen.
Research in vitro shows that TXL helps to inhibit the migration of various cancer cells, decreased the secretion of MMP-2, MMP-9, and uPA and the activity of ERK1/2 in cancer cells, and supress metastasis of cancer cells. Moreover, the research shows that TXL helps to inhibit tube formation of endothelial cells in vitro, decreased the secretion of MMP-2 and uPA in endothelial cells, and suppressed neovascularization of cancer cells. This suppression of tumor growth was associated with decreased microvessel formation and increased apoptosis caused by THL.
Experience of Using TXL by Lymphoma Clients Worldwide
Good Product Brings New Opportunity
Ma Meiyu, 46 years old at the time, from Thailand
Disclaimer: The picture on the left hand side is only for illustration. The information presented in this website is only for education purposes. This information does not substitute nor replace medical advice.
I went to the hospital because my throat felt uncomfortable. Initially the doctor’s diagnosis was minor inflammation and I was given an antiphlogistic. In September 1995 I felt an itching in my neck like a mosquito bite. I scratched the area and blood came out. Because the bleeding wouldn’t stop, I went to the hospital where they found a spleen tumor.
Fortunately, my husband works in a government office where we have a good standard of living and can afford Chinese medicine when undergoing medical treatment. We got information about TXL on the internet, a famous Chinese medicine. I went to a drugstore in Bangkok that sold Tian Xian Liquid and quickly drank it.
One day, I read a report about Tian Xian Liquid in a Hong Kong newspaper. I observed that the TXL packaging photo in the newspaper was very different from the TXL product packaging I bought at the drugstore in Bangkok. After I obtained the telephone number of China’s No. 1 Tian Xian Liquid agent, I immediately ordered the product from Hong Kong. Tian Xian Liquid sent from Hong Kong looks exactly like the photo in the newspaper.
After taking TXL for 1 month, the pain that constantly bothered me disappeared. 6 months later, the lymph node tumor shrank. Because I am also undergoing chemotherapy, of course not all of these healing effects come from Tian Xian Liquid.
When I thought I had recovered well, I stopped drinking Tian Xian Liquid and only relied on chemical treatment. I immediately felt weak, and as the disease started to come in full force, my pain returned. At this time, I rely on TXL, depending on my condition, I also use Tian Xian Suppository. My spleen tumor continues to shrink.
The Experience of Fighting Cancer 4 Times
Lady Matsuda, 57 years old at the time, Japan
Disclaimer: The picture on the left hand side is only for illustration. The information presented in this website is only for education purposes. This information does not substitute nor replace medical advice.
In 1993, I was hospitalized because of ovarian cancer. I underwent surgery and anti-cancer treatment. Although my energy and stamina had recovered, and I was back to living a normal life, I felt excruciating pain in my back in June 1995. I had a bad cough, and eventually couldn’t eat.
I saw a news report that terminal cancer patients at Chuan Yue Dai Jing San Hospital got better because they consumed Tian Xian Liquid. After reading this, I rushed to try TXL products.
In April of the following year, I returned to the hospital for 3 months to receive a bone stem cell transplant and anti-cancer treatment. I didn’t stop taking TXL. I knew beforehand that I would experience side effects from anti-cancer medicine such as loss of appetite and hair loss.
The doctor said frankly that the transplant was equivalent to a large amount of anti-cancer medicine. I suffered tremendous side effects because I was on 2 medical treatments at once. The treatment was finally finished, and I was allowed to go home from the hospital in January 1998. The tumor indicator at that time was 110.
I have been on the verge of death many times, only my passion for life can fight cancer. During my stay at the hospital, I got to know many patients but only a few survived. While undergoing anti-cancer treatment, I suffered from vomiting, constipation, and hair loss. But I am sure I can survive through all these difficulties.
A friend once said that disease is not necessarily related to the length of our lives. I agree with him. My good friend who didn’t feel any complaints suddenly collapsed due to a cerebral aneurysm and then died. I, on the other hand, a cancer patient, outlived my good friend.
